BOSTON — Bill Cosby’s wife refused to answer dozens of questions during a combative deposition in a defamation lawsuit filed by seven women who say the comedian branded them liars after they accused him of sexually assaulting them, according to a transcript released Friday.

Camille Cosby was subjected to intense questioning by the women’s lawyer, who repeatedly pressed her to say whether she believes her husband “acted with a lack of integrity” during their 52-year marriage. The lawyer also asked if her husband used his position and power “to manipulate young women.”

Camille Cosby didn’t answer those questions and many others after her lawyer cited marital privilege, the legal protection given to communications between spouses. She repeatedly said she had “no opinion” when pressed on whether she viewed her husband’s behavior as dishonest and a violation of their marriage vows.

About 50 women have publicly accused Bill Cosby of forcing unwanted sexual contact on them decades ago. Cosby has denied the allegations. He faces a criminal case in Pennsylvania, where prosecutors have charged him with sexually violating a former Temple University employee, Andrea Constand. He has pleaded not guilty.

Camille Cosby answered questions in the deposition Feb. 22 and again April 19 after her lawyers argued unsuccessfully to stop it. A judge ruled she would have to give a deposition but said she could refuse to answer questions about private communications with Cosby.